Saturday, October 7, 2017

थायराइड को उपचार (यहां वहां बाट संकलित ) -KRD (Part-03)

http://www.globalrph.com/labs_t.htm

T3 (Triiodothyronine) Free (serum) T3 (Triiodothyronine) Reverse (RT3) (serum)
T3 (Triiodothyronine) Total  (serum) T4 (thyroxine) Free (serum)
T4 (thyroxine) Total (serum) Testosterone - total (serum)
Thrombin time (plasma) Thyroglobulin (serum)
Thyroid-stimulating hormone (TSH)  (serum) Thyroxine-binding globulin (TBG) (serum)
Thyroid Function Tests Transferrin (serum)
Triglycerides (serum)

Lab (Specimen)

Conventional Units

SI Units

T3 (Triiodothyronine) Free (serum)
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0-6 years: 2.4 -4.2 pg/mL
7-17 years: 2.9-5.1 pg/mL
> 18 years old: 2.3- 4.2 pg/mL
3.5 - 6.5 pmol/L
T3 (Triiodothyronine) Reverse (RT3) (serum)
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Birth-6 days: 600 -2500 pg/mL
> 7 days old: 90 -350 pg/mL
Adults: 0.11 - 0.32 ng/ml
           0.04 - 0.29 nmol/L
T3 (Triiodothyronine) Total  (serum)

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Cord blood: 14 -86 ng/dL
1-7 days: 100 -470 ng/dL
8- 364 days: 105 -245 ng/dL
1 -9 years: 94 -269 ng/dL
10-19 years: 102 -200 ng/dL
> 20 years old: 80 -200 ng/dL
Adults: 0.8 - 2.0 ng/ml
           0.9 - 2.8 nmol/L
T4 (thyroxine) Free (serum)
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0.8 - 1.8 ng/dL 10 - 23 pmol/L
T4 (thyroxine) Total (serum)
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4.5 - 12.5 µg/dL 58 - 161 nmol/L
Testosterone - total (serum)

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Male: 300 to 1000 ng/dL
Female: < 62 ng/dL

ALT:
Male:
14-15 yr: 33-585 ng/dL
16-17 yr: 185-886 ng/dL
18-39 yr: 400-1080 ng/dL
40-59 yr: 350-890 ng/dL
> 60 yr: 350-720 ng/dL

Tanner Stage IV: 165-854 ng/dL
Tanner Stage V: 194-783 ng/dL
Male: 6.7 - 28.9 nmol/L
Female: < 2.1 nmol/L
Thrombin time (plasma)
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10 - 13.5  sec 10 - 13.5  sec
Thyroglobulin (serum)
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</= 60 ng/mL </= 60 µg/L
Thyroid-stimulating hormone (TSH)  (serum)

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0.5 - 4.70 µIU/mL

American Association of Clinical Endocrinologists guidelines changed their normal range for TSH to 0.3 - 3.04 mIU/L.
0.5 - 4.70 mIU/L
Thyroxine-binding globulin (TBG) (serum)
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Depending on the lab:
Electrophoresis:
10 - 24 mg/dL

Radioimmunoassay is used:
1.3 - 2.0 mg/dL
Depending on the lab:
Electrophoresis:
10 - 24 mg/dL

Radioimmunoassay is used:
1.3 - 2.0 mg/dL
Thyroid Function Tests
Alternative source:


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Thyroid Function Testing
Thyroid Function Test
Measurement
Normal Range
Total T4 (TT4) bound and free T4 4.5 -11.5 ug/dL
Free T4 (FT4) free T4 0.8 -2.8 ng/dL
Free T4 Index (FT4I) estimate of free T4
FT4I = TT4 x RT3U
1.0 -4.3 U
Total T3 (TT3) bound and free T3 75 -200 ng/dL
Resin T3 Uptake (RT3U) binding capacity of TBG 25 -35%
TRH TRH 5 -25 mIu/mL
TSH TSH 0.3 - 5.0 U/mL
Thyroglobulin Thyroglobulin 5-25 ng/mL
Radioactive Iodine Uptake (RAIU) Distribution of radiolabeled iodine in the thyroid 5 hr – 5 to 15%
24 hr – 15 to 35%
Notes:
Free T4
- much more useful than total T4 (e.g. interested in unbound or active form).  Total T4 not commonly measured. Greatly affected by TBG. 
Free T4 index
: indirect measure of free T4. Corrects for high/low values of TBG.
Total T3
: not as useful as free T3, however, may be useful in locating problems with TBG, or if looking for problems with peripheral conversion of T4 to T3. 
Resin T3 Uptake
: if low, then TBG binding capacity is high. Opposite if high.
TSH
: best measure to determine thyroid function. 
Thyroglobulin
: nonspecific test that is elevated when the thyroid gland is inflamed or enlarged. 
Transferrin (serum)
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188 - 341 mg/dL 1.88 - 3.41 g/L
Triglycerides (serum)

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NML: 30-149 mg/dL

Normal: < 150 mg/dL.
Borderline-high:
    150 to 199 mg/dL
High: 200 to 499 mg/dL
Very High: >499 mg/dL
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Important Notes   top of page icon

>Unless noted, all values are for adults.
>All laboratory values listed are method dependent (Methods include: immunoassay, colorimetry, electrophoresis, HPLC, etc).
>Values may vary between laboratories.

References

Basic Skills in Interpreting Laboratory Data, 5th Ed. (2013) Lee M (editor). American Society of Health-System Pharmacists, ISBN 1585283436.

Drug information handbook: a comprehensive resource for all clinicians and healthcare professionals, 24th Ed. (2015) Lexi-Comp.

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